Ozempic (semaglutide) is a medication used for type 2 diabetes and sometimes for weight loss. It comes in pre-filled pens with multiple doses.
Knowing how long an Ozempic pen lasts is important to use it effectively and avoid waste. This depends on the pen’s dose, how it’s stored, and its expiration date. According to the manufacturer and the FDA, an unopened Ozempic pen is good until its expiration date if kept in the fridge. Once opened, a pen typically lasts about 4 weeks.
In today’s article, we explore the pen’s design, dose configurations, shelf life factors, storage best practices, and user insights. This will help you plan your refills and make sure the medication works as it should.

Overview of Ozempic Pen Design and Dose Configurations
The Ozempic pen is a simple, disposable device for weekly injections. It comes in different strengths to accommodate starting and maintenance phases, directly impacting how long the pen lasts in terms of usable weeks.
- Starter Pen (0.25 mg/0.5 mg doses): This red-labeled pen contains 2 mg total, providing up to 8 doses at 0.25 mg (for the initial 4 weeks) and then 0.5 mg, allowing it to cover the titration period before switching to higher-strength pens.
- 0.5 mg Maintenance Pen: Blue-labeled with 4 mg total, it delivers 4 weekly doses of 0.5 mg, lasting one month.
- 1 mg Maintenance Pen: Yellow-labeled with 8 mg total, providing 4 weekly doses of 1 mg for a month’s supply.
- 2 mg Maintenance Pen: Green-labeled with 8 mg total, also yielding 4 weekly doses of 2 mg, sufficient for one month.
Each pen is designed to last for one month if you take your doses correctly. How long it lasts can change if you miss a dose or if your doctor changes your dose.
Shelf Life for Unopened Ozempic Pens
An unopened Ozempic pen is good until the expiration date on the box, which is usually 2 to 3 years. For the pen to last this long, you must store it in the refrigerator at a temperature between 36°F and 46°F (2°C to 8°C). Keeping it cold is important because the medicine inside, semaglutide, can be damaged by heat or cold.
If exposed to heat above 86°F or freezing, the pen’s integrity may be compromised, shortening its usable life even before opening. Pharmacists recommend checking the expiration upon receipt and planning refills accordingly to avoid gaps in therapy. For travel or storage, insulated cases can help maintain this extended duration without risking spoilage.
People also ask: What happens if I use Ozempic after 56 days
Factors Affecting Ozempic Pen Duration
Several factors affect how long an Ozempic pen lasts, even before its expiration date. Temperature is the most important factor. Unopened pens kept at room temperature can degrade faster than those stored in the refrigerator, especially in warm conditions.
Exposure to light can also cause the medication to break down more quickly, so it’s best to keep the pen in its original box to protect it from UV rays.
How often you take your dose and the strength of the medication also determine how long the pen will last. For example, a starter pen with a lower dose might last for several weeks as you slowly increase your dosage. In contrast, maintenance pens are designed to last for 4 weeks. Always check the solution is clear—cloudy means it’s ineffective.

Proper Storage Guidelines for Maximum Duration
Make sure your Ozempic pen lasts until its expiration, and follow Novo Nordisk’s storage protocols rigorously. Keep unopened pens in the refrigerator at a temperature between 36°F and 46°F.
Make sure they are not placed near the freezer, as freezing can damage the medication. Also, avoid storing them in the refrigerator door, where the temperature can change frequently.
Use insulated bags with ice packs for transport, but don’t let them touch directly to avoid freezing. If it gets warm (up to 86°F), it’s still safe just put it back in the fridge quickly to keep it lasting longer. These tips help protect the pen.
User Experiences: What Real People Say
Users on forums like Reddit and Drugs.com report that insulin pens last reliably until their expiration date when stored unopened in the refrigerator. One user shared, “My unopened pens are good for 2 years from manufacture.”
Positive Feedback:
“Stored properly, it lasts the full term without issues.”
Negative Feedback:
“Heat exposure shortened mine—had to discard early.”
Many users emphasize the importance of checking expiration dates to avoid waste.
Tips for Maximizing Ozempic Pen Duration
To extend usability:
- Refrigerate unopened pens immediately upon receipt.
- Use FIFO (first in, first out) for multiple pens.
- Protect from light with original packaging.
- Monitor fridge temperature with a thermometer.
- Plan travel with TSA-approved coolers.
These habits, from Healthline and GoodRx, prevent premature expiration.
When to Replace or Consult a Doctor
Know when it’s time to replace your Ozempic pen or talk to a doctor. You should get a new pen if it has been:
- Out of the fridge for more than 56 days.
- In temperatures below 36°F or above 86°F.
- The medicine looks cloudy, has particles, or has changed color.
Also, call your doctor if you have side effects that won’t go away, like upset stomach, throwing up, or belly pain.
Conclusion
When you don’t open it and keep it in the fridge, your Ozempic pen is good until the expiration date. Once you start using it, it can last for 4 to 8 weeks, depending on your dose. How you store and handle the pen is very important. Always keep track of dates to stay safe.
FAQs
How long does an unopened Ozempic pen last?
An unopened Ozempic pen lasts 2-3 years if kept in the fridge (36°F-46°F). Store it properly and check the label when you get it.
What is the dose configuration for Ozempic pens?
The starting pens (0.25/0.5 mg) give you 8 doses and can last up to 8 weeks. The other pens (0.5 mg, 1 mg, 2 mg) give you 4 doses and last for one month if you use them weekly.
What factors shorten Ozempic pen duration?
Heat above 86°F, freezing, or light exposure can reduce shelf life by degrading semaglutide. Improper handling like dropping may affect integrity. Keep them in the fridge to help them last longer.
How should I store unopened Ozempic pens?
Keep unopened pens in the fridge between 36°F and 46°F. Keep them in the box they came in to protect them from light. Don’t store them in the fridge door.
What if my Ozempic pen expires before use?
Throw away expired pens safely at pharmacy take-back programs. Ask your doctor for a new prescription. Expired pens may not work well.
Trusted Resources
- GoodRx: Should Ozempic Be Refrigerated? 5 Tips for Storage – https://www.goodrx.com/ozempic/does-ozempic-need-to-be-refrigerated
- Medical News Today: Does Ozempic need to be refrigerated? Storage and travel tips – https://www.medicalnewstoday.com/articles/drugs-does-ozempic-need-to-be-refrigerated
- Ozempic Official Site: How to Use The Ozempic Pen – https://www.ozempic.com/how-to-take/ozempic-pen.html
- Drugs.com: Does Ozempic need to be refrigerated? – https://www.drugs.com/medical-answers/ozempic-refrigerated-3542954/
- SingleCare: How long does Ozempic last? Shelf life and other considerations – https://www.singlecare.com/blog/ozempic-shelf-life/
- Reddit: Ozempic lasting longer than 56 days? – https://www.reddit.com/r/pharmacy/comments/1bla3rm/ozempic_lasting_longer_than_56_days/
- Healthline: How to Travel with Ozempic – https://www.healthline.com/health/drugs/how-to-travel-with-ozempic




