Does Ozempic Make You Pee More? Urinary Side Effects Examined

Ozempic (semaglutide) is a medication commonly used for type 2 diabetes and weight management. While its side effects mostly affect the stomach, some people wonder if it makes them pee more.

According to recent studies and reports, Ozempic isn’t a diuretic so it doesn’t directly cause more urination. However, some people might notice increased urination due to better blood sugar control (excess sugar leaving the body through urine) or dehydration from stomach-related side effects. This isn’t a common or listed side effect in FBA labeling, but it can happen, especially when starting the medication or increasing the dose.

In this article, we’ll explore the evidence, user experiences, and risk factors related to increased urination with Ozempic. We’ll also cover management strategies and when to seek help, using information from medical studies and trials to keep things simple and clear.

Overview of Ozempic and Its Known Side Effects

Ozempic is a once-weekly injection that helps control blood sugar, slow digestion, and reduce appetite. Over time, it can lead to better blood sugar management and weight loss of 10-15%.

The FDA-approved listed common side effects include nausea (up to 44%), vomiting (24%), diarrhea (30%), and abdominal pain, which affect the digestive system and can indirectly influence hydration and urinary patterns.

While increased urination isn’t a common side effect of Ozempic, some users have reported it. Here are a few reasons why this might happen:

Glucose Excretion: When blood sugar is high, Ozempic helps the body get rid of excess glucose through urine, which can lead to more frequent urination. This effect is more common in diabetics with uncontrolled blood sugar.
Rapid Weight Loss: According to a 2025 analysis from Aeroflow Urology, rapid weight loss can weaken pelvic floor muscles, potentially causing urinary incontinence.

However, sources like Drugs.com and Baptist Health clarify that Ozempic is not a diuretic (a drug that increases urination). In fact, by stabilizing blood sugar and body fluids, it might even reduce urination for some people.

Potential Mechanisms: How Ozempic Might Increase Urination

Ozempic helps control your blood sugar. When your blood sugar is high, the drug helps your body get rid of extra sugar through your pee. This process, called glycosuria, pulls more water along with the sugar, which makes you have to pee more. Additionally, side effects like diarrhea or vomiting can make you dehydrated. When you drink more fluids to rehydrate, you’ll naturally urinate more.

Rapid weight loss can weaken pelvic muscles, which might lead to incontinence or urgency. Wellness Briefs’ 2025 review also links it to a higher risk of UTIs due to slower digestion. Natura Dermatology explains that as your kidneys clear out extra sugar, you might pee more often. This side effect is rare and doesn’t affect everyone.

User Experiences: What Real People Say

User feedback from sites like Reddit and Facebook shows that some people mention peeing more, but not very often. This is usually linked to stomach issues or changes in blood sugar.

Positive: Many users report no changes in urination. One user noted, “No peeing more, but urine smells different sometimes.”
Mixed: Some experienced temporary changes. For example, one user shared, “Pee more during the first week due to diarrhea dehydration, but it normalized afterward.”
Negative: A few reported more serious issues. One user stated, “Frequent urination and incontinence started after losing 30 lbs, likely due to a weakened pelvic floor.”

These reports highlight varying experiences, with most changes being temporary or conditional.

Drugs.com reviews note occasional “pee more” complaints amid nausea, but it’s not dominant. Overall, it’s a minor concern that resolves for most.

Risk Factors and Who Might Be Affected

People with high blood sugar levels may urinate more often due to sugar in their urine. Women who lose weight may have a higher chance of bladder leaks because of weaker muscles. Older adults or those with kidney problems are at risk of dehydration.

Managing Increased Urination on Ozempic

Drink 8-10 glasses of water a day to stay hydrated, and try electrolyte drinks if you’re feeling dehydrated. Doing Kegel exercises can help strengthen your pelvic floor muscles and reduce incontinence.

Monitor blood sugar to minimize glycosuria.
Eat fiber-rich foods to ease diarrhea.
Use absorbent products if needed temporarily.

These from Aeroflow and Polar Bear Meds prevent complications.

When to Consult a Doctor

See a doctor if you’re peeing a lot (more than 8 times a day), it hurts, or there’s blood in it these could be signs of a UTI or kidney problems. If you keep feeling dehydrated, get checked out right away.

Conclusion

Ozempic might make some people pee more because of extra sugar leaving the body or slight dehydration. But this isn’t a common side effect and is usually easy to handle. Stay hydrated and check in with your doctor if you’re worried.

FAQs

Does Ozempic directly cause increased urination?

Increased urination isn’t a common side effect of Ozempic, but it can happen due to glucose in the urine or dehydration from stomach issues. It’s more common with uncontrolled diabetes. Stay hydrated and talk to your doctor if it continues.

How does Ozempic lead to more frequent peeing?

Ozempic helps control blood sugar, but it can cause more sugar and water to leave your body in urine. It may also cause diarrhea and leading to dehydration and more thirst. These side effects usually get better with time.

Who is more likely to pee more on Ozempic?

Diabetics with high blood sugar or those experiencing strong GI side effects are at greater risk, as glucose excretion rises. Women with weight loss may face incontinence from muscle weakening. Proper management reduces incidence.

What to do if Ozempic makes you pee more?

Drink plenty of water and drinks with electrolytes. Watch your blood sugar levels. Do Kegel exercises if you have trouble holding your pee. Eat fiber to help with diarrhea.

Are there alternatives to Ozempic if urination increases?

Yes, other GLP-1s like Trulicity may have milder GI effects; SGLT2 inhibitors intentionally increase urination but manage diabetes differently. Lifestyle changes could substitute.